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The recruitment of TAMs is an active process largely driven by ROS

In this setting as well, treatments with antioxidant substances could be appropriate, but literature data indicate that antioxidants alone are unable to induce significant clinical changes, except perhaps in mild forms, and must be used in conjunction with standard drug treatments to achieve measurable results (124)

There is no cure for migraine, and current medications primarily provide symptomatic relief and may not be suitable for all patients (Yamanaka et al., 2021)

This lack of transparency undermines trust in the models results and limits its adoption in clinical practice